| abstract |
The invention relates to the technical field of biomedical materials, in particular to tussah silk fibroin hydrogel and a preparation method and application thereof. The invention provides a preparation method of tussah silk fibroin hydrogel, which comprises the following steps: (1) mixing tussah silk fibroin and quaternary ammonium salt, and carrying out ring-opening addition reaction to obtain quaternized tussah silk fibroin; (2) and mixing the quaternized tussah silk fibroin and N-isopropyl acrylamide, and carrying out in-situ polymerization reaction under the action of an initiator to obtain the tussah silk fibroin hydrogel. The tussah silk fibroin hydrogel prepared by the method has good biocompatibility and strong cell adhesion capability, can promote cell proliferation, and has good mechanical property, temperature responsiveness and antibacterial property. |