| abstract |
The invention discloses a preparation method of tenofovir alafenamide (TAF), which is based on (R)-2-(6-amino-9 H -purine-9-yl) isopropoxymethyl N' -[(S)-1-Isopropoxyformyl]ethylphenoxyphosphinamide (2) is the raw material, after amidation reaction, oxidation reaction and hydrolysis reaction, and then split to obtain tenofovir alafenamide (TAF,1). The invention has the advantages of green environmental protection, pollution-free, environment-friendly, easily available raw materials, wide sources, low cost, simple method and suitability for industrialized production, and the preparation method solves the problems of high preparation cost and difficulty in industrialized production in the prior art . |