http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110627725-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 2019-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110627725-B |
| titleOfInvention | A kind of 4-substituted 5-difluoromethyl-3-nitro-1H-pyrazole compound and its preparation method and application |
| abstract | The invention belongs to the technical fields of chemistry and medicine, and provides 4-substituted 5-difluoromethyl-3-nitro-1H-pyrazole compounds and a preparation method and application thereof; the compounds have the structure shown in the following formula. The compound of the present invention introduces a difluoromethyl group on the pyrazole structure, which improves the biological activity of the pyrazole structure. Due to the potential biological activity of the pyrazole skeleton and the important role of difluoromethyl in medicinal chemistry, this type of substance provides more possibilities for the preparation of medicinally active molecules. The present invention adopts two-bottle reaction system, so that difluoroethylamine does not contact with nitroalkene, avoids the occurrence of aza-Michael addition reaction, and prepares difluoromethyldiazomethane and nitroalkene through ex-situ [3+ 2] cycloaddition reaction, successfully obtained 4-substituted 5-difluoromethyl-3-nitro-1H-pyrazole compounds. In addition, the preparation method of the present invention has the advantages of mild reaction conditions, readily available raw materials, and good substrate universality. |
| priorityDate | 2019-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.