| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y502-01008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-104
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y502-01008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-407 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 |
| filingDate |
2018-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e68e277abc3e105a20cd36043d53d87e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c901c405fb120d14435d9b37e258538
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93582c7ce0d8b00e903aedef5bc93763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809f9d7ca331206051b382f37d887de6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7b35d05887297508ef4b651edd115e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d74160d8b4f18a8e6bf882959221ebb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f445c3f48c45ddf1ae89ecb32fff1b2b |
| publicationDate |
2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110621322-A |
| titleOfInvention |
Tunable endogenous protein degradation with heterobifunctional compounds |
| abstract |
The present invention provides a method of modulating gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knockout or knockin strategies and strategies that provide single nucleotide corrections or alterations. The invention comprises the in-frame insertion into the genome of nucleotides encoding a heterobifunctional compound targeting protein (dTAG) with a nucleotide sequence encoding an endogenously expressed protein of interest which, when expressed, produces an endogenously expressed protein. Derived protein-dTAG hybrid protein. This allows targeted proteolytic degradation of the dTAG and the fused endogenous protein using heterobifunctional compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111606969-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116082308-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111549000-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112266404-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114748479-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112662676-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114748479-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113735828-A |
| priorityDate |
2017-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |