| abstract |
Complement factor D inhibitors, pharmaceutical compositions and uses thereof, and methods for their manufacture are provided. Provided compounds include Formula I, Formula II, Formula III, Formula IV, and Formula V, or pharmaceutically acceptable salts, prodrugs, isotopic analogs, N-oxides, or isolated isomers thereof, which may be any Optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or modulate the complement cascade. |