http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110590956-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1278 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-40 |
| filingDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110590956-B |
| titleOfInvention | Novel bi-specific protective antibody composed of two anthrax non-protective antibodies |
| abstract | The invention discloses a novel bi-specific protective antibody consisting of two anthrax non-protective antibodies, wherein variable regions of a heavy chain and a light chain of the antibody are respectively formed by connecting variable regions of two different epitopes of an anti-anthrax bacillus PA antigen in series, and the variable regions of the heavy chain and the light chain have unique CDR regions. The bispecific antibody provided by the invention introduces a new neutralization mechanism through screening and combination of parent antibodies, has furin enzyme PA83 inhibitory activity and LF cleavage MEK inhibitory activity which are concentration-dependent, has more obvious antibody neutralization activity and animal protection rate than the parent antibodies used singly or in a mixed way, and shows good application prospect in preparing drugs for treating and/or preventing Bacillus anthracis infectious diseases. |
| priorityDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 633.