http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110590911-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2019-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110590911-B |
| titleOfInvention | Synthetic method and application of polypeptide containing tyrosine sulfating modification |
| abstract | The invention provides a synthesis method and application of a polypeptide containing tyrosine sulfation modification. The method adopts an Fmoc solid-phase polypeptide synthesis method, takes Fmoc amino resin as a carrier, sequentially condenses Fmoc protected amino acids from C end to N end according to a polypeptide sequence containing a tyrosine sulfation modification site, and obtains linear peptide amino resin; wherein, the tyrosine side chain sulfate adopts neopentyl as a protecting group, and the cysteine side chain adopts trityl and/or acetamidomethyl as a protecting group; then removing side chain protecting groups by a proper reagent, and cracking and purifying the target polypeptide from the resin to obtain the polypeptide containing tyrosine sulfation modification. The invention is helpful for researching the influence of tyrosine sulfation modification on the biological activity of the polypeptide and related mechanisms, and lays a good foundation for the diagnosis and treatment of related diseases. |
| priorityDate | 2019-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.