| abstract |
The present invention discloses a kind of 7-p-benzoic acid azo petracenin and its preparation method and application, a kind of preparation method of the 7-p-benzoic acid azo petracenin of claim 1 of the present invention, comprises the following Steps: (1) First use p-aminobenzoic acid and sodium nitrite as raw materials, dissolve p-aminobenzoic acid in dilute hydrochloric acid, and then add sodium nitrite aqueous solution under the condition of stirring in an ice-salt bath, the temperature of the ice-salt bath is 0-5°C , to obtain aniline diazonium salt through diazotization reaction; (2) aniline diazonium salt is coupled with petracenin compound, stirred under alkaline conditions, and when petracenin is dissolved in sodium hydroxide, add aniline diazonium salt After the reaction, the weak acidity is modulated to the end of the reaction, and 7-p-benzoic acid azo-petrousnin is obtained; the 7-p-benzoic acid azo-petrousnin obtained by the present invention is tested for antitussive activity, and the results show that it has a good effect on antitussive activity. The role of the compound, and the compound has better water solubility, better activity, less toxicity, and increased bioavailability. |