http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110590667-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110590667-B |
| titleOfInvention | 3-trifluoromethyl substituted pyrazole derivative and synthesis method and application thereof |
| abstract | The invention belongs to the technical field of medical material synthesis, and particularly relates to a 3-trifluoromethyl substituted pyrazole derivative and a synthesis method thereof. The derivative is prepared by mixing aldehyde, sulfonyl hydrazide, 2-bromo-3, 3, 3-trifluoropropene, alkali and an organic solvent I for reaction or mixing hydrazone, 2-bromo-3, 3, 3-trifluoropropene, alkali and the organic solvent I for reaction. The method is efficient, the reaction has good adaptability to functional groups, the adaptability to substrates is wide, and the product yield is high; the raw materials are cheap and easy to obtain, the scale can be enlarged to a level of ten grams or larger, the operation is simple and safe, and the reaction condition is mild. The obtained product comprises key intermediates for constructing COX-2 inhibitors Colecoxib and Mavacoxib, lung cancer inhibitors SC-560 and measles virus inhibitors AS-136, has wide application in the fields of pesticides, medicines and materials, and has good industrial application prospect. |
| priorityDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.