http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110590487-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-12 |
| filingDate | 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110590487-B |
| titleOfInvention | Ruthenium-catalyzed ortho-meta selective hydrogen-deuterium exchange reaction of benzene ring |
| abstract | The invention discloses a ruthenium-catalyzed ortho-meta selective hydrogen-deuterium exchange reaction of a benzene ring. Specifically, the invention provides a preparation method of a deuterium-labeled compound shown as a formula I, which comprises the following steps: under the catalysis of dichlorobis (4-methyl isopropylphenyl) ruthenium, a compound shown as a formula II reacts with deuterated acetic acid in the presence of silver acetate and triphenylphosphine to obtain a deuterium-labeled compound shown as a formula I. The invention adopts dichlorobis (4-methyl isopropyl phenyl) ruthenium as a catalyst, widens the application range of a guide group, is not limited to groups such as pyrazole, pyridine and the like, such as other nitrogen heterocyclic aromatic rings, for example: pyrazine, pyrimidine, benzimidazole and the like can well induce the high-efficiency hydrogen and deuterium exchange of ortho-position and meta-position of a benzene ring, and the highest deuterium substitution rate can reach 95%. The reaction of the invention can simultaneously realize ortho-meta deuteration of benzene ring, can introduce a plurality of deuterium atoms, provides another simple and efficient method for synthesis of internal standard reagent, and has higher social benefit and economic benefit. |
| priorityDate | 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.