http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110585143-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F26B5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F26B5-06 |
| filingDate | 2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110585143-B |
| titleOfInvention | Neostigmine mesylate freeze-dried preparation for injection and preparation method thereof |
| abstract | The invention relates to a neostigmine mesylate freeze-dried preparation for injection and a preparation method thereof. Neostigmine methosulfate injection is unstable to light and heat, and mainly degrades 3-hydroxytrimethylidine methosulfate which is an impurity and has a genotoxicity warning structure. In order to improve the stability of the freeze-dried preparation, the inventor carries out dosage form improvement on the freeze-dried preparation, and obtains the freeze-dried preparation product through prescription screening and process improvement. The obtained product has good appearance, good re-solubility and good clarity, the main degradation impurity 3-hydroxytrimethylidene methosulfate is greatly reduced, and the safety and the stability of the product are improved. |
| priorityDate | 2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.