Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9faa4a6e4abd919be6a2eb7d5bd68785 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 |
filingDate |
2018-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100c17ded1634d8cf7bf44e881aa112d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abbb8d5f3b99d6b0316c4d631377585f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5dc786faf008d30a438ca6a7a1a7175 |
publicationDate |
2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-110577932-A |
titleOfInvention |
A cord blood-derived chimeric antigen receptor T cell |
abstract |
The invention provides a chimeric antigen receptor T cell derived from umbilical cord blood and its preparation and application in tumor treatment. Specifically, the present invention provides a cord blood-derived CAR-T cell, which expresses a chimeric antigen receptor CAR, and whose HLA-I gene expression is silenced in the CAR-T cell. The CAR-T cells of the present invention will not cause the rejection of the allogeneic cells by the host T cells, will not cause the killing effect or weak killing effect of the host NK cells, survive longer in the body, and can exert the specific anti-tumor effect of allogeneic transplantation . |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113528455-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113005094-A |
priorityDate |
2018-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |