http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110573152-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110573152-B |
| titleOfInvention | Pharmaceutical composition containing pyrazole derivatives as active ingredients for preventing or treating pruritus |
| abstract | The present invention relates to a pharmaceutical composition for preventing or treating pruritus, comprising a pyrazole derivative as an active ingredient, and a screening method for its detection. The pharmaceutical composition for preventing or treating pruritus according to the present invention can relieve pruritus symptoms by inhibiting the activity of intracellular Mrgpr X1, and can relieve itching symptoms by inhibiting the activity of intracellular hH1R, so that it can also be used for prevention or treatment Medications for histamine-mediated pruritus. In addition, it has been confirmed by a mouse model experiment of dry skin that the composition also has a significant relieving effect on dry skin, so that it can be used as a drug for treating dry skin. In addition, the pharmaceutical composition according to the present invention can relieve itching symptoms caused by psoriasis, and thus can also be used as a drug for treating psoriasis. Moreover, the pharmaceutical composition according to the present invention can maintain stable activity even during in vivo administration without causing adverse reactions. |
| priorityDate | 2017-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 222.