http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110563649-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110563649-B |
| titleOfInvention | High-selectivity deuteration method of 2-methyl nitrogen heterocyclic compound |
| abstract | The invention discloses a high-selectivity deuteration method of a 2-methyl nitrogen heterocyclic compound, which comprises the following steps: adding a 2-methyl nitrogen-containing heterocyclic compound shown in a formula I, a formula II or a formula III, an oxidant and an additive into a dried Schlenk reaction tube, adding deuterium water and an organic solvent into the reaction tube under the condition of protective gas, stirring and reacting for 2-12 hours at 50-100 ℃, and obtaining reaction liquid, and respectively obtaining the deuterated nitrogen-containing heterocyclic shown in a formula IV, a formula V or a formula VI after post-treatment. The method is based on a free radical process, is high-efficiency, can synthesize the methyl-d 3 substituted nitrogen heterocyclic compounds which are difficult to prepare by the existing method, and has high reaction deuteration rate; the method is carried out under a neutral condition, and the requirement on equipment is low; the catalytic amount of the oxidant is used, and the additive is cheap and easy to obtain; the reaction conditions are mild, and the energy consumption is saved; high yield, strong substrate universality, simple and convenient operation and the like. |
| priorityDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.