http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110558279-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2019-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110558279-B |
| titleOfInvention | Drug screening model, drug screening method and application thereof |
| abstract | The invention provides a drug screening model, a drug screening method and application thereof, wherein the drug screening model is dhx33 gene defective zebra fish. The invention adopts dhx33 gene defective zebra fish as a drug screening model, the dhx33 gene can not normally express, the p53 gene and the downstream p21 and caspase8 genes thereof are both expressed and increased, the number of apoptotic cells is obviously increased, the head and eye phenotypes are obviously reduced compared with the head and eye phenotypes of wild zebra fish embryos, the phenotype change can be recovered by the treatment of a p53 inhibitor, and the dhx33 gene defective zebra fish has the potential of the drug screening model as the p53 inhibitor. |
| priorityDate | 2019-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 303.