| abstract |
The present invention relates to a bispecific antibody and its preparation method and application. The bispecific antibody of the present invention comprises a CD20-binding domain, a CD3-binding domain, and a heterodimeric Fc region, the CD20-binding domain and the CD3-binding domain each independently selected from the group consisting of Fab region, ScFv region or sDab region. The bispecific antibody of the present invention can stably and efficiently target CD20 and CD3, and can mediate the specific killing of tumor cells by T cells. |