| abstract |
A class of furanocoumarins- Base derivative, whose structural formula is shown in the following formula 6 or 7, is synthesized from p-bromoaniline, paraformaldehyde, 4-hydroxycoumarin, isonitrile, n-butyllithium, etc. through cyclization and coupling reactions. The reaction conditions required by the process are mild, the reaction time is short, and the yield is high. Coumarin fragments of the present invention Base derivatives, with excellent luminescence properties and high biological activity, some of which have anti-tumor activity, and showed highly selective inhibition of human triple-negative breast cancer cells (MDA-MB-231), which have potential for further development as anti-tumor drugs Research value; some other products can be used for simultaneous detection of neuroblastoma metabolites homovanillic acid (HVA) and mandelic vanillic acid (VMA), which have the potential to be developed as highly efficient fluorescent probes for early warning and diagnosis of human neuroblastoma. |