http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110540535-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110540535-B |
| titleOfInvention | Process suitable for preparing 4- (6-aminopyridin-3-yl) substituted piperidine in amplification way |
| abstract | The invention discloses a process method suitable for preparing 4- (6-aminopyridine-3-yl) substituted piperidine in an amplifying way, belonging to the field of synthesis of pharmaceutical intermediates. N-substituted piperidone, aryl sulfonyl hydrazide and 2-amino-5-bromopyridine are subjected to coupling reaction in the presence of a palladium catalyst, and then hydrogenation reaction is carried out to obtain the 4- (6-aminopyridine-3-yl) substituted piperidine ester. In the process, raw materials in pyridine do not need to be protected, condensation and coupling are carried out in the same reaction kettle, the operation cost is reduced, the steps of protection and deprotection in documents are avoided, the production cost of the conventional biological, medical and chemical intermediates is greatly reduced, the process is subjected to scale-up verification on a kilogram scale, the yield and the product purity are basically equivalent to a gram-scale, and the process can be used as a process for industrial scale production. |
| priorityDate | 2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.