http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110540504-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-86 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-33 |
| filingDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110540504-B |
| titleOfInvention | Preparation method of ingenane diterpene and application thereof in pharmacy |
| abstract | The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a preparation method of ingenane diterpene and application of the ingenane diterpene in preparation of anti-HIV drugs. The invention enriches ingenane diterpenoid ingredients from Euphorbia (Euphorbia ebracteolta) of Euphorbia (Euphorbia) and performs content determination of main active ingredients and anti-HIV activity test, and the result shows that: with the increase of the content of the ingene diterpenoid ingredients, the anti-HIV activity is in a clear rising trend; when the content of ingenol-type total diterpene in the enriched component is more than 47%, the enriched component shows strong anti-HIV activity, EC 50 The value reaches 0.0063 mug/mL, and the cytotoxicity is low (CC) 50 14), Selection Index (SI) greater than 2000, with clear advantages compared to the positive control drug zidovudine. The invention establishes a method for rapidly enriching ingenane total diterpenes from euphorbia ebracteolata and the enriched ingenane total diterpenes can be used for preparing anti-HIV drugs. |
| priorityDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.