| abstract |
The invention discloses an application of crocin-I in preparing a medicine for reducing fat accumulation. The crocin-I of the invention can act on the synthesis and metabolism pathway of liver lipids, and reduces the accumulation of lipids in the liver. Reduced serum triglycerides, total cholesterol and the ratio of low-density lipoprotein to high-density lipoprotein. In addition, crocin-I effectively mediated the improvement of lipid metabolism and reduced the elevated content of hepatic metabolites caused by CORT treatment, mainly concentrated in long-chain saturated or unsaturated fatty acids such as palmitic acid, oleic acid, and arachidonic acid. Expression of genes in the fatty acid synthesis pathway and cholesterol metabolism genes in mouse liver. |