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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-56
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-56
filingDate 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110526895-B
titleOfInvention Preparation and separation method of raloxifene dimer
abstract The invention discloses a preparation and separation method of raloxifene dimer. Raloxifene hydrochloride is used as a raw material, and is polymerized under the action of hydrogen peroxide, alkyl diamine and ferric trichloride to generate a crude product of raloxifene dimer; and purifying the raloxifene dimer crude product by preparative chromatography to obtain a raloxifene dimer refined product. The preparation method and the separation method of the raloxifene dimer have the advantages of simplicity in operation, environmental friendliness, low cost and high purity of the obtained dimer, and lay a good foundation for the quality research and control of the raloxifene.
priorityDate 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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