http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110526868-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110526868-B |
| titleOfInvention | A kind of preparation method of celecoxib |
| abstract | The invention relates to a preparation method of celecoxib, which belongs to the technical field of preparation methods of raw materials. In the preparation method of celecoxib according to the present invention, firstly, 4-hydrazinobenzenesulfonamide described in formula II is reacted with acetaldehyde to obtain a reaction solution containing the compound of formula III; then, into the reaction solution obtained in the first step, adding formula The p-toluoyl chloride described in IV obtains a reaction solution containing formula V; in the reaction solution obtained in the second step, hydrochloric acid ethanol is added to obtain compound VI, which is then closed with 1,1,1-trifluoroacetone to form a plug Lecoxib. The change of the ring mode fundamentally avoids the generation of regioisomer impurities. This preparation method uses a one-pot reaction for upper protection, condensation and deprotection. The reaction conditions are mild, the post-processing operation is simple, and the total yield can reach 90%. The above is more suitable for large-scale industrial production. |
| priorityDate | 2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.