| abstract |
The invention relates to a fluorine substituted diphenylethane derivative which is characterized in that the structure is shown as a general formula (I): wherein: r 1 Is methyl or ethyl; r 2 Is hydrogen or fluorine; r is hydrogen, hydroxyl, benzyloxy, phosphate or phosphate ester salt. Compared with the prior art, the invention carries out fluorine substitution modification on the bridge bond of the diphenylethane, the obtained fluorinated diphenylethane derivative has stronger in-vitro anti-tumor activity, and the introduction of fluorine atoms changes the physical, chemical and biological properties of the compound and has obvious inhibition effect on tumor cells. |