http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110522948-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2371-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2471-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2305-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L71-02 |
| filingDate | 2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110522948-B |
| titleOfInvention | Injectable hydrogel and preparation method and application thereof |
| abstract | The invention discloses an injectable hydrogel and a preparation method and application thereof. The hydrogel comprises A hydrazide group modified hyaluronic acid derivative HA-ADH, an aldehyde group, A bifunctional hyaluronic acid derivative A-HA-Dop with catechol modified in A side chain and an aldehyde group-terminated polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer A-PEO-PPO-PEO-A. On one hand, aldehyde-terminated A-PEO-PPO-PEO-A can be self-assembled into micelles, and A hydrogel first network is constructed by utilizing the characteristic of thermosensitive sol-gel transition; on the other hand, aldehyde groups on the surface of the A-PEO-PPO-PEO-A micelle and aldehyde groups on the A-HA-Dop can form acylhydrazone bonds with hydrazide groups on the HA-ADH under A physiological environment to construct A second cross-linked network and A third cross-linked network of the hydrogel. By physical acting force and reversible dynamic covalent bond acting force, the injectable multi-network cross-linked hydrogel (HA-Dop/PF) which HAs dual responsiveness of pH and temperature, quick self-healing, high stability, high adhesiveness, easy extension and easy compression is obtained, and can be applied to the biomedical fields of tissue repair materials, drug controlled release and the like. |
| priorityDate | 2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.