http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110507825-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6933 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 |
| filingDate | 2018-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110507825-B |
| titleOfInvention | Polypeptide polymer and preparation method and application thereof |
| abstract | The invention provides a polypeptide polymer, wherein the self-assembly polypeptide comprises a polymer carrier module, a functional module and a response module, wherein the polymer carrier module, the functional module and the response module are formed by diacrylate polycondensates; the polypeptide polymer provided by the invention can be self-assembled under a weak acid condition, can stably exist in a single chain form and reach a tumor part, can permeate to a deep tumor part by virtue of a small particle size, and can be hydrolyzed under the weak acid stimulation of a tumor microenvironment (the pH value is about 6.5), the hydrophobicity of the polypeptide polymer is greatly increased, so that the polypeptide polymer is greatly increased, and then self-assembly aggregation is carried out, the generated aggregated nanoparticles have higher cell-entering capacity and tumor cell killing capacity, and a new effective strategy is provided for improving the capacity of nano-drugs in permeating, cell-entering, enriching and the like at the tumor part. |
| priorityDate | 2018-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.