http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110498841-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate | 2018-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110498841-B |
| titleOfInvention | Method for synthesizing head-tail cyclic peptide containing alanine |
| abstract | The invention relates to a method for synthesizing head-tail cyclic peptide containing alanine, which comprises the following steps: 1) selecting solid-phase synthetic resin; 2) firstly, Fmoc-Asp (OH) -OAll is coupled with solid-phase synthetic resin, then NH2-Asp- (solid-phase synthetic resin) -OAll is obtained according to Fmoc/tBu solid-phase synthetic strategy, and amino acid residues in a peptide sequence are coupled in sequence to obtain NH2-AAn-Asp- (solid-phase synthetic resin) -OAll; 3) removing a protecting group All from a solid phase to obtain NH2-AAn-Asp- (solid phase synthetic resin) -OH; 4) under the solid phase condition, carrying out head-tail condensation cyclization on head-tail amino acid of the polypeptide long chain obtained in the step 3); 5) cracking the product obtained in the step 4) to obtain solid-phase synthetic resin, and preparing intermediate cyclic peptide crude peptide; 6) and (3) removing side chain carboxyl of terminal aspartic acid from the intermediate cyclopeptide crude peptide under the action of decarboxylase to obtain a finished product. |
| priorityDate | 2018-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.