abstract |
The invention discloses staurosporine derivatives which can be used for developing anti-tumor related medicaments and medicaments for inhibiting related diseases with kinases such as protein kinase, tyrosine kinase and the like. The invention also provides a preparation method of the staurosporine derivatives, which is obtained by separating and purifying a fermentation crude extract obtained by fermenting the actinomycete rice solid culture medium and extracting the fermentation crude extract by ethyl acetate by adopting gel column chromatography, silica gel column chromatography, medium-pressure preparative chromatography and high performance liquid chromatography, and is easy to operate and implement. The staurosporine derivative has a novel structure type and is found in natural products for the first time; the invention has simple experiment operation, easy expanded production and better application prospect. |