abstract |
The present invention discloses a novel monoclonal antibody targeting AXL and an antibody-drug conjugate. The invention also discloses a method for preparing the antibody and the antibody-drug conjugate. The AXL antibody of the present invention can efficiently and specifically bind to purified human AXL protein and AXL on the surface of various tumor cells, and the humanized antibody also has high affinity and low immunogenicity. Antibody-drug conjugates have significant anti-tumor effects on tumor cells with high AXL expression. |