http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110483549-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110483549-B |
| titleOfInvention | Preparation method of nitroimidazole pyran antituberculosis drug |
| abstract | The invention relates to a preparation method of a nitroimidazole pyran antituberculosis candidate drug PA-824. The method relates to five-step reaction, which comprises the steps of firstly obtaining a key intermediate 6 through nucleophilic substitution, hydrolysis and silicon etherification, and then obtaining a final product PA-824 through O-alkylation and cyclization reactions. The raw materials needed by the whole reaction are cheap and easy to obtain, the use of explosive raw material 2, 4-dinitroimidazole is avoided, the reaction condition is mild, the operation is simple, and the large-scale production is easy. |
| priorityDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.