| abstract |
The invention discloses a method for synthesizing iodobenzoxeptanone seven-membered ring lactone without metal catalysis, and belongs to the technical field of organic chemistry. Using compound 3 or 4 as a raw material and reacting in the presence of an iodination reagent, a base and an organic solvent, the iodobenzoxeptanone seven-membered ring lactone 1 or 2 of the present invention can be obtained in one step, respectively. The method of the invention, the simple method of iodination reaction while synthesizing seven-membered ring lactone, solves the technical problem of iodination at the same time of seven-membered ring lactone; The reaction reagents are expensive, the catalysis cost is high, the reaction requires a high temperature environment, and it cannot be prepared in large quantities; by adopting this method, a series of iodo derivatives of benzoxeppanone and its analogs can be obtained. |