| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c27f4a786895417d03d0b1045587100 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-05 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-05 |
| filingDate |
2019-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d6547b1329efb64e52623f75191bfaf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7219da2952e9f0d1f5aae7cbfd9bc108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eaac82b743a3ce93d04a9d4a097dd88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bd67cb724cbdab6e08e453244825fe8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf18ea1431174746979e3c46cf7453c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7552d60808ab3a1453cd450376cb218 |
| publicationDate |
2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110478337-A |
| titleOfInvention |
Application of Honokiol and Honokiol in the Preparation of MCR-1 Enzyme Inhibitors |
| abstract |
The invention provides an application of honokiol and honokiol in the preparation of MCR-1 enzyme inhibitor, and provides a new medical application of honokiol and honokiol in the preparation of MCR-1 enzyme inhibitor, It is disclosed that honokiol and honokiol can inhibit the activity of MCR-1 enzyme and restore the bactericidal activity of polymyxin on MCR-1 Enterobacter. In the in vivo experiments, the combination of honokiol and honokiol with polymyxin has a good therapeutic effect on bacterial infections expressing MCR-1, especially the infections caused by MCR-1-positive Enterobacteriaceae, and has a wide range of medical applications. use. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113209058-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116270473-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021068614-A1 |
| priorityDate |
2019-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |