http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110478322-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110478322-B |
| titleOfInvention | Nucleic acid drug compound and preparation method and application thereof |
| abstract | The invention provides a nucleic acid drug compound and a preparation method and application thereof, wherein the nucleic acid drug compound consists of a branched chain structure, a functional element modified on the branched chain structure and a bridging structure connected with the branched chain structure; the branched chain structure comprises a supramolecule and a nucleic acid branched chain connected to the supramolecule; the functional element is assembled on the supermolecule of the branched chain structure through host-guest recognition; the bridging structure comprises complementary strands of nucleic acid branches, disulfide bonds and nucleic acid drug; the bridging structure serves as a connecting chain to connect a plurality of branched structures to form a nucleic acid drug complex. The prepared nucleic acid drug compound can be loaded with functional elements such as targeted delivery, controllable release and the like by reasonable structural design and sequence design and combining the host-guest recognition function of a supramolecular system, realizes the targeted delivery and controllable release of nucleic acid drugs, and has important application value in the fields of early diagnosis of diseases, treatment of genetic diseases, tumor treatment and the like. |
| priorityDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.