| abstract |
The present invention provides a method for preparing a dinucleotide prodrug with a novel structure and its application in preparing a drug for treating viral infections, especially hepatitis B virus (HBV) infection and HBV-related liver diseases. These dual nucleoside precursor compounds can significantly improve their targeting in the liver, and improve their accumulation capacity in the liver, further effectively improve the efficacy and activity, and reduce the dosage, thereby reducing the toxic and side effects; high oral bioavailability, The advantages of good stability in the stomach and long in vivo half-life. The preparation method of the dinucleotide prodrug provided by the present invention is simple, and it does not need to be purified after the multi-step reaction, and can be directly put into the next reaction, thereby simplifying the operation steps. |