| abstract |
The invention discloses a pyrazole bipyridone compound, which is a structure shown in the following general formula (1) and general formula (2) or a pharmaceutically acceptable salt or solvate thereof. The invention also discloses an intermediate for preparing the above-mentioned pyrazole bipyridone compounds. The invention also discloses a method for preparing the above pyrazole bipyridone compound and the application of the above pyrazole bipyridone compound. The pharmacological activity screening test of the compound of the present invention proves that this kind of compound with brand-new structure shows strong inhibitory activity on tumor growth. The IC 50 of some compounds has reached about 22nM, and the activity of some compounds is better than that of the positive control SR141716, which is an excellent tumor treatment drug. Research offers new ideas. The preparation method of the compound in the invention has reasonable design, readily available raw materials, simple and convenient operation, and is suitable for industrialized production. |