http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110467575-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110467575-B |
| titleOfInvention | Synthesis and preparation method of phenobarbital-D5 for court science qualitative and quantitative use |
| abstract | The invention discloses a synthetic preparation method of phenobarbital-D5 for qualitative and quantitative use in forensic science, which comprises the following steps: (1) taking 2-phenylmalonate as a raw material, and carrying out substitution reaction on the 2-phenylmalonate and deuterated bromoethane under the action of alkali to obtain 2- (ethyl-D5) -2-phenylmalonate; (2) the 2- (ethyl-D5) -2-phenylmalonate is subjected to amine transesterification with urea in situ without separation to obtain D5-deuterated phenobarbital. The synthetic preparation method of the phenobarbital-D5 for qualitative and quantitative court science has the advantages of mild reaction conditions, simplicity in operation, high yield of 70-80%, high quality of the D5-deuterated phenobarbital standard product synthesized by the method, high purity of 99.768%, high stability and the like. |
| priorityDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.