http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110452215-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2018-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110452215-B |
| titleOfInvention | Preparation method of erlotinib intermediate and erlotinib |
| abstract | The invention relates to an erlotinib intermediate and a preparation method of erlotinib. The method comprises the steps of carrying out condensation, hydrolysis ester group and dimethylamine hydrochloride amination on 2-nitro-4-cyanobenzene acetate and 2-methyl-2- (4-ethyl-3-substituted) phenyl propionate/propionyl chloride, then carrying out reduction-cyclization reaction to obtain an intermediate 2,3, 6-trisubstituted indole derivative, and carrying out cyclization reaction on the intermediate and a cyclization reagent to prepare the Alletinib. The method has the advantages of cheap and easily-obtained raw materials, short process flow, safe and simple operation, high unit reaction selectivity and small amount of waste water, and is favorable for realizing green and simple production of the alendronic. |
| priorityDate | 2018-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.