http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110448698-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4152 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4152 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-52 |
| filingDate | 2019-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110448698-B |
| titleOfInvention | A kind of drug controlled release mesoporous silicon nanoparticles and preparation method thereof |
| abstract | The invention discloses a drug controlled-release mesoporous silicon nanoparticle and a preparation method thereof, wherein the preparation method comprises the following steps: (1) adding 3-aminopropyltriethoxysilane to the mesoporous silicon nanoparticle to Toluene is used as a solvent, and the reflux reaction is performed under the protection of nitrogen. After the reaction is completed, it is washed with ultrapure water and ethanol, and dried in vacuum to obtain aminated mesoporous silicon nanoparticles MSN-NH 2 ; (2) dissolving the aminated mesoporous silicon nanoparticles In acetonitrile, add 1-pyrene formaldehyde for reaction, after the reaction, centrifuge, wash with ultrapure water and ethanol, and vacuum-dry to obtain MSN-N=CH-Py; (3) Take MSN-N=CH-Py, add the required The loaded drug solution is reacted, and after the reaction is completed, β-cyclodextrin is added to continue the reaction. After the reaction is completed, it is centrifuged, washed with ultrapure water and ethanol, and vacuum-dried to obtain the product. The drug controlled-release mesoporous silicon nanoparticle of the present invention has good response to pH, and has good drug loading capacity and drug controlled release performance. |
| priorityDate | 2019-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.