http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110437118-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b54afeb9f498bae7db63345da54b8359 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-04 |
| filingDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81995835f86ffe43ecbadf25a8fc5466 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f2b56d8fe9e875bb18361b8cf30c73a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_973e89d8bc168cbc8543a38e6514c973 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12495b879a8983d5fb1a30f14543d1ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c568e15aa60f69d8e2a12364cefa6b02 |
| publicationDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110437118-A |
| titleOfInvention | The preparation method of azaheterocyclic carboxylic acid intermediate and azetidine -3- carboxylic acid |
| abstract | The invention discloses the preparation methods of azaheterocyclic carboxylic acid intermediate and azetidine -3- carboxylic acid, are related to pharmaceutical chemistry technical field.The preparation method for being used to prepare the azaheterocyclic carboxylic acid intermediate of azetidine -3- carboxylic acid includes: to mix nitrogen heterocyclic and Wittig reaction reagent to carry out Wittig reaction and isolated azepine cyclopropane carboxaldehyde intermediate；Azepine cyclopropane carboxaldehyde intermediate is subjected to oxidation reaction and isolated azaheterocyclic carboxylic acid intermediate；Wherein, nitrogen heterocyclic is selected from least one of 1- benzhydryl-3-aza ring butanone, 1- benzyl azetidine -3- ketone, 1-Boc azetidine -3- ketone and 1- acetyl group azepine pyridine -3- ketone.The preparation method of azetidine -3- carboxylic acid is that azaheterocyclic carboxylic acid intermediate is carried out to hydrogenolysis, and with short production cycle, safe preparation process is reliable, production cost is low, and purity is greater than 98%, and yield can achieve 82.8%. |
| priorityDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.