| abstract |
The invention discloses a synthesis method of carboxylic acid ester compounds, and relates to the technical field of organic synthesis. The synthesis method of the carboxylate compound uses a fluorine-containing coupling agent, and the specific steps are as follows: 1) Add the fluorine-containing coupling agent and N-methylmorpholine at a ratio of 1:1 to 2 Add anhydrous tetrahydrofuran to the reactor, and stir under N 2 protection at 0-5°C for 5-20 min; 2) Add the carboxylic acid compound into the reactor, continue to react for 15-45 min, and then add the alcohol Add the compound into the reactor, react at room temperature for 48-60 h, and stop the reaction; 3) Remove solid impurities by filtration, remove the organic solvent by rotary evaporation, and obtain the carboxylate compound by ethanol recrystallization or column chromatography. The invention provides a method for synthesizing carboxylate compounds, which can reduce the reaction difficulty of synthesizing carboxylate compounds, and realize efficient synthesis of carboxylate compounds under mild conditions at room temperature. |