http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110433333-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-45 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110433333-B |
| titleOfInvention | Metal organic framework/electrospun fiber composite material with NO and copper ion slow-release synergistic effect and preparation method and application thereof |
| abstract | The invention belongs to the field of biological materials, and particularly relates to a metal organic framework/electrospun fiber composite material with a slow-release synergistic effect of NO and copper ions, and a preparation method and application thereof. The material is a patterned structure formed by mutually interweaving core-shell structure fibers, wherein the core-shell fibers take hydrophobic biological materials as a core layer and hydrophilic biological materials as shell layers, and the core layer is coated with NO-loaded copper-based MOF. The preparation method comprises the following steps: the preparation method comprises the steps of dispersing the NO-loaded copper-based MOF by adopting a patterned receiving template, communicating an organic solvent for dissolving the hydrophobic biological material with an inner needle of a coaxial electrostatic nozzle, communicating an organic solvent for dissolving the hydrophilic biological material with an outer needle of the coaxial electrostatic nozzle, and carrying out coaxial electrostatic spinning. Aiming at the problems of slow repair rate of the diabetic wound surface, insufficient angiogenesis and the like, NO slowly released by the material and copper ions have synergistic effect, so that angiogenesis and collagen deposition in wound healing are promoted, inflammatory reaction is reduced, and the like, and the healing period of the diabetic wound surface is greatly shortened. |
| priorityDate | 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.