http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110433150-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173291be3daa44875b077d3fe4ac9fc7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4669ef4f665c8c3d7e2ff487310ba163 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c0474fed73b9e7c1af8b726729068ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fef1388b8c1d201e34a703966d54182a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e393cf5d60a2b3ba88dca95643907f81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a05de0474a7cfb83e920cf0336ad8891 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_189b33425f6419bfdcf18283ababd56d |
| publicationDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110433150-A |
| titleOfInvention | Application of acetylshikonin in the preparation of drugs for the prevention and treatment of colon cancer |
| abstract | The invention discloses the application of acetylshikonin in the preparation of drugs for preventing and treating colon cancer. The present invention verifies that acetylshikonin plays a significant role in the prevention and treatment of colon cancer by targeting TOPK on human colon cancer cell lines. The inventors treated colon cancer cell lines and TOPK-overexpressed human colon cancer PDX mouse models with acetylshikonin. At the end of the experiment, they found that acetylshikonin could inhibit the growth of colon cancer cells. Acetylshikonin drug treatment Compared with the control group, the tumor volume of mice in the control group has a significant statistical difference, thus showing that acetylshikonin has a significant effect on the prevention and treatment of colon cancer through TOPK. Colon cancer with high expression of TOPK can be prevented and treated clinically by giving acetylshikonin to patients. The acetylshikonin of the present invention can target the kinase TOPK, and is applicable not only to colon cancer but also to other cancers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114933522-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114933522-A |
| priorityDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.