| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cedae1e4103c4e3719a5e9c94c2b510 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-025 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0605
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-39 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate |
2019-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f58c4807d0142f2cb7714413894ad9d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9b632c0364222e140e48a1f78a4051f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b7c983460ebd5a7d9e8fc997ffee049
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_049f6ccb80f3a585d730ebd9f9a3b866 |
| publicationDate |
2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110423720-A |
| titleOfInvention |
A method for inducing amniotic epithelial stem cells to differentiate into functional pancreatic beta cells and its application |
| abstract |
The invention discloses a method for using human amniotic epithelial stem cells to induce differentiation into pancreatic islet β cells with biological functions, comprising the following steps: 1) isolation, cultivation, expansion and identification of amniotic epithelial stem cells; 2) in vitro differentiation: experiment Amnion epithelial stem cells of the 2nd to 3rd passages were selected, and the medium containing nicotinamide was used to induce differentiation. After 14 days of differentiation in vitro, insulin-secreting cells capable of expressing islet β-cell-specific markers and having normal islet β-cell function were obtained; 3) In vivo transplantation: transplanting the induced insulin-secreting cells into type 1 diabetic mice can significantly Alleviate hyperglycemia in mice. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112063577-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111793596-A |
| priorityDate |
2019-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |