http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110423487-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B23-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 |
| filingDate | 2019-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110423487-B |
| titleOfInvention | Rhodol derivative dye and application thereof |
| abstract | The invention relates to a Rhodol derivative dye and a photoacoustic imaging PA probe, in particular to preparation and application of the Rhodol derivative dye and the photoacoustic imaging PA probe. The new Rhodol derivative dye Rhodol-NIR designed and synthesized by the invention has a large molar extinction coefficient, excellent photostability and ideal quantum yield, and shows excellent photophysical properties when designing a high-contrast activated PA probe. The Rhodol-PA probe designed and synthesized by the invention is proved to show high sensitivity and high selectivity detection on hNQO1 through PA absorption and fluorescence measurement in vitro. The invention develops the high-contrast activatable PA probe by utilizing the spironolactone ring-opening conversion strategy for the first time at home and abroad. The switching strategy of the present invention is a universally applicable design that can provide a new platform for developing high contrast activatable PA probes. |
| priorityDate | 2019-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.