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filingDate 2017-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110418848-A
titleOfInvention Methods for diagnosing prostate disease by bacterial metagenomic analysis
abstract The present invention relates to a method for diagnosing prostate diseases such as prostate cancer, benign prostatic hyperplasia, etc. by bacterial metagenomics analysis, and more particularly to by performing bacterial metagenomic analysis with a sample derived from a subject, and analyzing extracellular bacteria derived from specific bacteria A method of diagnosing prostate cancer or benign prostatic hyperplasia by increasing or decreasing the content of vesicles. Extracellular vesicles secreted from bacteria present in the environment can be absorbed into the body and directly affect the occurrence of inflammation and cancer, and it is difficult to diagnose prostate diseases such as prostate cancer and benign prostatic hyperplasia at an early stage before any symptoms appear, which makes effective treatment variable. difficult. Therefore, according to the present invention, the risk of prostate cancer and benign prostatic hyperplasia can be predicted in advance by the metagenomic analysis of genes present in bacterial-derived extracellular vesicles using human-derived samples, so that prostate cancer can be diagnosed and predicted in advance. Disease-risk groups, and delaying or preventing onset with appropriate care allows early diagnosis of prostate cancer and benign prostatic hyperplasia, which can reduce the incidence of prostate disease and improve treatment outcomes.
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