| abstract |
The present invention provides a kind of separation methods of Impurities In Analgin, comprise the following steps: (1) analgin with solvent is uniformly mixed, then rising temperature for dissolving, active carbon is added, then heat filter, filtrate concentration；(2) it with the concentration filtrate in methanol dissolving step (1), is separated with silica gel plate, chooses destination layer scraper plate, dissolved with dosage methanol, filtering is concentrated to get object crude product；(3) object crude product separates and collects maximum polar compound mobile phase with preparation liquid phase, is concentrated to get target impurity；The present invention separates Impurities In Analgin, help to carry out it is qualitative after go to trace its Producing reason, advanced optimize the generation that technique avoids this impurity, finally further increase product quality. |