http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110396095-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f70ff6a368a35c671913556bb8c18e04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 |
| filingDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4571854233af978334cf8d82bbdb9cbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f89be8a0cb03640fd301f63fa1b3e9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_133be301d8145b00272bd1757c9646b6 |
| publicationDate | 2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110396095-A |
| titleOfInvention | A kind of furanopyrimidine double aromatic ring derivative epidermal growth factor inhibitor and its preparation method and use |
| abstract | A furanopyrimidine double aromatic ring derivative epidermal growth factor inhibitor and its preparation method and use. The invention discloses a selective inhibitor of clinical mutants of EGFR protein tyrosine kinase, and has the structure as formula (I and II), which is a kind of furanopyrimidine-containing double aromatic ring template compound, and also discloses The preparation method of the compound and its application as the selective inhibitor of the clinical mutant of EGFR protein tyrosine kinase, especially the inhibitory effect on the T790M variant epidermal growth factor receptor EGFR, and in the treatment with epidermal growth factor Overexpression of the receptor EGFR is associated with diseases such as kidney cancer, lung cancer, prostate cancer, pancreatic cancer, breast cancer and glioblastoma. . |
| priorityDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 609.