http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110393803-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6939 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 |
| filingDate | 2019-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110393803-B |
| titleOfInvention | Paclitaxel and polypeptide co-delivery system, preparation method and application |
| abstract | The disclosure belongs to the technical field of antitumor drug delivery, and particularly relates to a paclitaxel and polypeptide co-delivery system, a preparation method and application. In the prior art, the combination of immunotherapy and chemotherapy has good effect on tumor treatment. Alloferon-1, a basic peptide, has been studied in recent years to show that the polypeptide can promote immune system function by activating NK cells in the tumor microenvironment. The inventor considers that the combination of Alloferon-1 and paclitaxel is expected to have good treatment effect, in order to realize the co-delivery of the two drugs, the disclosure provides a PTX-DOTAP @ Alloferon-1-Heparin/Protamine nano co-delivery system, based on the degradation effect of heparanase-1 in a tumor microenvironment on Heparin, the disintegration of the whole system at a tumor part and the enrichment of drugs are realized, and the system has good effect particularly when being applied to the treatment of melanoma. |
| priorityDate | 2019-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.