http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110393714-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-243 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110393714-B |
| titleOfInvention | A kind of antitumor drug, synthesis method and application |
| abstract | The invention belongs to an antitumor drug, a synthetic method and application, in particular to a helicene molecule 4-aza[4]helicenium quaternary ammonium salt ([4]helicenium) drug, a synthetic method and its application in antitumor, nitrogen Hetero[4]helicene is a class of derivatives of fused-ring aromatic hydrocarbons with non-planar structure. The quaternization of aza[4]helicene can significantly increase the water solubility of the molecule and the binding ability to DNA, which can be highly efficient. It can effectively inhibit various cancers such as liver cancer, lung cancer, leukemia, etc. It is particularly noteworthy that [4]helicenium has no obvious toxicity to normal cells and tissues while killing tumor cells and tissues, and has excellent tumor selectivity. Chemotherapy-like drug-resistant tumors are also well inhibited. The [4]helicenium involved in the present invention has the advantages of simple preparation method, good water solubility and obvious curative effect on selective tumor inhibition, and has the properties of broad spectrum, high efficiency and low toxicity, and especially has wide application prospects in the field of traditional tumor chemotherapy. |
| priorityDate | 2019-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.