| abstract |
Provided herein are anti-human 4-1BB antibodies and fragments thereof having one or more structural features absent from the reference anti-human 4-1BB antibody, wherein the features may improve certain aspects of the antibody relative to the reference antibody feature. Also provided are various in vitro and in vivo methods and reagents related to the anti-human 4-1BB antibodies described herein. Methods include, for example, inducing T cell proliferation using anti-human 4-1BB antibodies and fragments thereof, inducing T cell secretion of IFNγ, and detecting, preventing and/or therapeutically treating cancer. |