| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-646 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2457
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 |
| filingDate |
2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110372747-B |
| titleOfInvention |
C containing trifluoromethyl3Ligand TunePhos and its synthesis method |
| abstract |
The invention discloses a trifluoromethyl-containing C 3 The TunePhos ligand is prepared from chiral diol, and then the ligand and 2-fluoro-4-bromobenzotrifluoride are subjected to aryl nucleophilic substitution reaction to obtain ether, and then lithium bromine exchange is performed under the action of a lithium reagent, and the ether is reacted with diphenyl phosphorus chloride, and then hydrogen peroxide is used for oxidation. Then iodo under the action of a lithium reagent and iodine, coupling with Ullmann, and finally reducing to obtain the electron-deficient ligand with trifluoromethyl introduced on the symmetry axis. |
| priorityDate |
2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |